Abstract

MARQUES, Gabriela Franco et al. Sulfone syndrome: a severe hypersensitivity reaction. Hansenol. int. (Online) [online]. 2012, vol.37, n.2, pp. 86-90. ISSN 1982-5161.

Dapsone is a drug used to treat leprosy and other skin diseases. Even in normal doses can cause a condition called sulfona syndrome, characterized by fever, hepatitis exfoliative dermatitis, generalised lymphadenopathy, hemolytic anemia and atypical lymphocytes in peripheral blood. It's a rare and severe hypersensitivity reaction to sulfone with an unpredictable clinical course. The authors report a case of sulfone syndrome, emphasizing its main clinical, laboratory and histopathological findings.

Keywords : Leprosy; Dapsone; Drug Hypersensitivity.