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BIS. Boletim do Instituto de Saúde (Impresso)

versión impresa ISSN 1518-1812


VENANCIO, Sonia Isoyama; PAIVA, Rui de; TOMA, Tereza Setsuko  y  BONFIM, José Ruben de Alcântara. Methylphenidate in the treatment of attention deficit disorder and hyperactivity in children and adolescents. BIS, Bol. Inst. Saúde (Impr.) [online]. 2013, vol.14, n.2, pp. 237-246. ISSN 1518-1812.

Methylphenidate is a central nervous system stimulant with more prominent effects on mental activity than in motor activity. The mode of action is not fully known, but a key action seems to be the inhibition of dopamine transport. It is indicated as part of a comprehensive program of treatment of attention deficit disorder and hyperactivity (ADHD), which should include psychological, educational and social measures, in adults and children above 6 years of age. This review assessed the efficacy and safety of methylphenidate in the treatment of children and adolescents diagnosed with ADHD. Search of bibliographic resources was carried out in December 2012 in the database Center for Reviews and Dissemination (CRD), in order to identify releases of Health Technology Assessment. From 54 entries, three were selected for analysis. After analysis of these documents was held search for randomized controlled trials in EMBASE and PubMed databases, published 1 June 2010 to 22 February 2013, but none were selected for analysis. Evidence points behavioral therapies as first choice in the treatment of ADHD in children up to 6 years old. Above this age methylphenidate is indicated as drug of choice and should be considered an association with behavioral therapies, especially for children up to twelve years.

Palabras llave : Methylphenidate; Attention Deficit Hyperactivity Disorder; Children and Adolescents.

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