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BIS. Boletim do Instituto de Saúde (Impresso)

versión impresa ISSN 1518-1812


TOMA, Tereza Setsuko et al. Low molecular weight heparins for prophylaxis and treatment of deep venous thrombosis in pregnancy. BIS, Bol. Inst. Saúde (Impr.) [online]. 2013, vol.14, n.2, pp. 229-236. ISSN 1518-1812.

Introduction: Deep venous thrombosis (DVT), highly prevalent disorder, is characterized by acute thrombus formation in veins of the deep system. A pregnant presents a six fold increased risk of thromboembolism due to DVT. Unfractionated heparins (UFH) and fractionated heparin (LMWH) have been prescribed for thromboprophylaxis during pregnancy. Objective: This study was undertaken to meet the demand of the Coordinator for Science, Technology and Strategic Supplies of the Health Secretariat of São Paulo State since LMWH enoxaparin has been the subject of lawsuits and administrative process. Methods: We performed an analysis of evidence on the efficacy and safety of enoxaparin compared with other heparins or placebo. A search was conducted of 28/11/2012 to 03/12/2012 in the following databases of scientific literature: Centre for Reviews and Dissemination, The Cochrane Library by BVS, PUBMED, EMBASE, LILACS, SciELO Regional and International Prescrire. Six systematic reviews were selected for analysis. Results: No evidence of high quality state that enoxaparin sodium is different from other LMWH for efficacy and safety in the prophylaxis and treatment of deep venous thrombosis in pregnancy. There is evidence that they cause fewer episodes of bleeding than unfractionated heparins. Conclusion: It is recommended that requests for LMWH lawsuits or administrative process for SES-SP are met by providing dalteparin sodium (included in the List of Essencial Medicines), considering dose adjustments to be defined by the prescriber.

Palabras llave : Enoxaparin; Heparin; Deep Venous Thrombosis.

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