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BIS. Boletim do Instituto de Saúde (Impresso)

Print version ISSN 1518-1812

Abstract

TOMA, Tereza Setsuko; VENANCIO, Sonia Isoyama; MARTINS, Patrícia Nieri  and  SATO, Helena Keico. Prophylactic use of palivizumab in the prevention of respiratory syncytial virus infection in high-risk children. BIS, Bol. Inst. Saúde (Impr.) [online]. 2013, vol.14, n.2, pp. 213-220. ISSN 1518-1812.

The palivizumab, a humanized IgG1 monoclonal antibody, was registered in the National Health Surveillance Agency - ANVISA in 1999. Usually, 5 doses monthly / child beginning before the seasonality of RSV are  sufficient. Objective: to determine whether prophylaxis with palivizumab reduces hospitalization and mortality from RSV infection in high-risk children. Methods: A search looking for reports on Health Technology Assessment, systematic reviews and randomized clinical trials was carried out in scientific literature databases. A number of the Boletim da Rede Brasileira de Avaliação de Tecnologias em Saúde, published in 2011, contained a technical report on palivizumab and was taken as a reference. An update task was carried out from three systematic reviews presented in this bulletin. Results: The results of the reviews were similar, showing that prophylaxis with palivizumab was effective in reducing the number of hospitalizations. The results regarding the reduction of mortality are still controversial. Conclusion: The palivizumab is dispensed by the Health Secretariat of São Paulo State since 2007. The Ministry of Health decided in 2012 by the incorporation of palivizumab for premature infants with gestational age less than or equal to 32 weeks and children up to 2 years with chronic lung disease or congenital heart disease.

Keywords : Palivizumab; Respiratory Syncytial Virus; Hospitalization.

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