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BIS. Boletim do Instituto de Saúde (Impresso)

versión impresa ISSN 1518-1812


TOMA, Tereza Setsuko; ALMEIDA, Eduardo Fonseca de; CINTRA, Eliane de Araújo  y  NASCIMENTO, Andréia de Fátima. Abatacept for patients with rheumatoid arthritis refractory to treatment with drugs modifying the disease course. BIS, Bol. Inst. Saúde (Impr.) [online]. 2013, vol.14, n.2, pp. 179-186. ISSN 1518-1812.

Rheumatoid arthritis (RA) is a systemic inflammatory, chronic and progressive disease which affects the synovial membrane, joints, bones and cartilage. The goals of management of RA are control pain and stiffness, reduce loss of function and joint failure, improve quality of life. Anti-inflammatory drugs and analgesics are used for relief of symptoms. Medicines called disease-modifying antirheumatic drugs (DMARD) biological or nonbiological are used to reduce joint damage. The biological DMARD suppress the immune system and inflammatory response. Abatacept is a selective immunomodulating biological drug which inhibits T lymphocytes. The aim of this article is to discuss scientific evidence on effectiveness and safety of abatacept in the treatment of RA refractory to the use of biological and DMARD. Documents were searched on the literature databases PubMed, EMBASE, TRIP DATABASE, Google Scholar, SciELO and LILACS, from 2009 to 2012. It has identified 360 studies and 19 of them selected. Abatacept is recommended for patients with severe RA who do not respond to at least two regimens with no biological drugs.  It is an option for the refractory cases of treatment with anti-cytokine biological anti-TNF.

Palabras llave : Abatacept; Biological Drugs; Rheumatoid Arthritis.

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